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Mir-187 microRNA precursor family : ウィキペディア英語版 | Mir-187 microRNA precursor family In molecular biology mir-187 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-187 has been found to be expressed at higher levels in ovarian cancers compared with benign tumours.〔 〕 It is known to target DAB2 (disbaled homolog-2), a protein encoded by the ''DAB2'' gene, with miR-187's target site at the 3'UTR of the ''DAB2'' gene. DAB2 has been seen to play roles in both cell proliferation and tumour progression, and initial expression of miR-187 in cancer cells promotes cell proliferation. However, overexpression suppresses DAB2 and inhibits epithelial to mesenchymal cell transition. High miR-187 levels have accordingly been associated with higher survival rates in ovarian cancer patients.〔 〕 == See also ==
* MicroRNA
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